Confirm 8-hour fast and then weigh the patient (kg). Determine the number of Macrilen™ pouches needed to prepare the dose.
Macrilen™ is designed for in-office administration1
The following steps show how to prepare and administer Macrilen™. Refer to Prescribing Information for complete instructions on how to prepare, dose, and administer Macrilen™ oral solution.

Verify patient details
- <120 kg=1 pouch
- >120 kg=2 pouches

Dissolve Macrilen™ granules in water
Fill the beaker with the appropriate volume of water. Tap water can be used. Add the granules into the beaker to dissolve.
- 1 pouch=120 mL water
- 2 pouches=240 mL water

Stir gently (2-3 minutes)
A small amount of undissolved particles will remain. The final concentration is 0.5 mg/mL. Use the Macrilen™ solution within 30 minutes of preparation.

Determine recommended dose
Determine the recommended dose to be administered by multiplying the patient weight in kilograms by 0.5 mg/kg.
Example: A patient weighing 70 kg will need a 35-mg dose of reconstituted Macrilen™ solution. Note: 2.2 lb=1 kg.

Determine and measure the exact volume
Determine the volume of prepared Macrilen™ solution to be administered by dividing the recommended dose by 0.5 mg/mL.
Draw up the exact volume of reconstituted solution in milliliters using the dose-measurement syringe.

Transfer exact volume
Transfer the exact required volume of Macrilen™ solution into the drinking cup. Reconstituted solution is stable for up to 30 minutes. Discard any leftover solution.


Three steps to complete the test1
Three steps to complete the test1

Drink
The patient must drink the entire volume of Macrilen™ solution within 30 seconds. Observe the patient for the duration of the test.

Draw
No baseline blood draw is required with Macrilen™. After administering Macrilen™, draw venous blood samples at 30, 45, 60, and 90 minutes.

Diagnose
After preparing the serum samples according to instructions from the lab (where samples will be sent), you will receive the growth hormone determinations.
How to interpret test results
How to interpret test results
Test results are considered positive for AGHD if the maximally stimulated serum GH level observed after stimulation is <2.8 ng/mL for the 4 blood draws.1
Preparing your patients
The What to Expect Patient Guide gives patients some baseline information to help prepare for their test.
Preparing your patients
The What to Expect Patient Guide gives patients some baseline information to help prepare for their test.
AGHDiagnose Kit

The complimentary AGHDiagnose Kit comes with tools to help you prepare and administer Macrilen™ solution.
Macrilen™ is ordered separately. This kit is not required to prepare Macrilen™.
Macrilen™ Solution

To obtain Macrlien™, complete the form on the Order and Support page. You can also find resources here for you and your patients, from co-pay help to communication tools.